Cafiso D S
Department of Chemistry and Biophysics Program, University of Virginia, Charlottesville 22901, USA.
Toxicol Lett. 1998 Nov 23;100-101:431-9. doi: 10.1016/s0378-4274(98)00217-3.
General anesthetics alter both the membrane dipole potential and the membrane spontaneous curvature, two membrane properties that are likely to have a significant effect on membrane protein function. The dipole potential is a large hydrocarbon positive potential that appears to arise from the lipid carbonyl groups and/or water at the membrane-solution interface. Anesthetics reduce the magnitude of the membrane dipole potential at clinical levels of anesthetics, while non-anesthetics do not, and these changes in potential could modulate conformational transitions in membrane proteins that are electrically active. When the membrane distribution of anesthetic versus non anesthetic compounds is examined, anesthetics exhibit a preference for the membrane interface, whereas non-anesthetic compounds reside within the membrane hydrocarbon core. The preferential localization of anesthetics within the interface accounts for their effect on the membrane dipole potential, and may also serve to alter the membrane spontaneous curvature or lateral stress through the bilayer.
全身麻醉药会改变膜偶极子电位和膜自发曲率，这两种膜特性可能对膜蛋白功能产生重大影响。偶极子电位是一种较大的烃类正电位，似乎源于膜 - 溶液界面处的脂质羰基和/或水。在临床麻醉药浓度下，麻醉药会降低膜偶极子电位的大小，而非麻醉药则不会，并且这些电位变化可能会调节电活性膜蛋白的构象转变。当研究麻醉药与非麻醉药化合物在膜中的分布时，麻醉药表现出对膜界面的偏好，而非麻醉药化合物则存在于膜烃核内。麻醉药在界面内的优先定位解释了它们对膜偶极子电位的影响，并且还可能通过双层改变膜自发曲率或侧向应力。
