Heil S H
Department of Psychology, Dartmouth College, Hanover, New Hampshire, 03755, USA.
Horm Behav. 1999 Feb;35(1):47-54. doi: 10.1006/hbeh.1998.1495.
While prolactin (PRL) has been reported to increase food intake by virgin female rats, its effects on food intake by male rats are relatively unexplored. The present studies examined the possibility that PRL has sex-specific effects on food intake by rats. In the first study, intact female and male rats were given subcutaneous injections of saline vehicle or ovine (o) PRL (1.0 mg/kg) twice daily at 08:00 and 20:00 h for 10 days. Food intake, body weight, and water intake were measured daily. Results indicate that oPRL administration increased food intake by an average of 4.5 g per day in female subjects, but did not significantly alter body weight or water intake. Male rats treated with oPRL did not significantly alter their food intake, even after an additional five days of treatment. In the second study, a wide range of oPRL doses (vehicle, 0.02, 0.2, 2.0, and 20.0 mg/kg/day) were tested in gonadectomized female and male rats. The results indicate that female rats responded to increasingly larger doses of oPRL with greater increases in food intake, with a maximum increase of approximately 6. 1 g per day at a dose of 20.0 mg/kg. In contrast, male rats maintained baseline levels of intake across all oPRL doses tested. These data suggest that PRL has sex-specific effects on food intake.
虽然有报道称催乳素（PRL）会增加未交配雌性大鼠的食物摄入量，但其对雄性大鼠食物摄入量的影响相对未被充分研究。本研究探讨了PRL对大鼠食物摄入量有性别特异性影响的可能性。在第一项研究中，对完整的雌性和雄性大鼠每天08:00和20:00皮下注射生理盐水或羊（o）PRL（1.0 mg/kg），持续10天。每天测量食物摄入量、体重和饮水量。结果表明，给予oPRL后，雌性大鼠的食物摄入量平均每天增加4.5 g，但体重和饮水量没有显著变化。用oPRL治疗的雄性大鼠即使在额外治疗五天后，其食物摄入量也没有显著改变。在第二项研究中，在去势的雌性和雄性大鼠中测试了广泛的oPRL剂量（生理盐水、0.02、0.2、2.0和20.0 mg/kg/天）。结果表明，雌性大鼠对越来越大剂量的oPRL反应是食物摄入量增加幅度更大，在20.0 mg/kg的剂量下，每天最大增加约6.1 g。相比之下，雄性大鼠在所有测试的oPRL剂量下都保持基线摄入水平。这些数据表明PRL对食物摄入量有性别特异性影响。
