Musselius S G, Vasina N V, Gladskikh L V
Anesteziol Reanimatol. 1998 Nov-Dec(6):49-53.
Therapeutic effect of lyophilized xenogenic hepatocytes was demonstrated on 30 dogs with acute hepatic failure and on white mice. The major biochemical values were corrected and the yeast fermentation test showed biological activity of isolated hepatocytes. Clinically, lyophilized hepatocytes were used in the treatment of patients with acute hepatic failure: orally in 47 and for extracorporeal dialysis in 8. The therapeutic effect of lyophilized hepatocytes is based on active detoxication and hemostasis correction. Clinical, laboratory, and instrumental studies showed improvement of the clinical status, decreased encephalopathy, and accelerated repair processes in the liver. Addition of lyophilized hepatocytes to combined therapy decreased the mortality by 2.5 times.
冻干异种肝细胞对30只急性肝衰竭犬和小白鼠的治疗效果得到了证实。主要生化指标得到纠正，酵母发酵试验显示分离出的肝细胞具有生物活性。临床上，冻干肝细胞用于治疗急性肝衰竭患者：47例口服给药，8例用于体外透析。冻干肝细胞的治疗效果基于积极的解毒和止血纠正。临床、实验室和仪器研究表明，患者临床状况改善，脑病减轻，肝脏修复过程加快。在联合治疗中添加冻干肝细胞可使死亡率降低2.5倍。
