Hayashi Y, Tachibana O, Muramatsu N, Tsuchiya H, Tada M, Arakawa Y, Suzuki M, Yamashita J
Department of Neurosurgery, Kanazawa University School of Medicine, Japan.
J Comput Assist Tomogr. 1999 Jan-Feb;23(1):34-8. doi: 10.1097/00004728-199901000-00008.
At least one type of Rathke cleft cyst has unique MR findings, specifically, high intensity on T1-weighted images and iso- to low intensity on T2-weighted images relative to white matter. To clarify the influence of cyst content on MR images, we analyzed the cyst content by biomedical methods after surgical removal.
We studied five patients diagnosed with Rathke cleft cyst, whose MR images showed high intensity on T1-weighted images and iso- to low intensity on T2-weighted images. After surgery, total protein and cholesterol levels were quantified, and correlations of protein and cholesterol content with T1 and T2 signal intensities were performed in vitro.
All five cysts had very high concentrations of protein (11,700-26,600 mg/dl, mean 17,940 mg/dl) with nearly no cholesterol (at most 2.0 mg/dl). Along with increases in protein concentration in vitro, the signal intensity of T1-weighted images increased, while that of T2-weighted images decreased. In contrast, the cholesterol concentration sequence influenced the signal intensity of neither T1- nor T2-weighted images.
The unique MR finding of Rathke cleft cysts--high signal intensity on T1-weighted images and low signal intensity on T2-weighted images--might depend mainly on protein concentration, not on cholesterol.
至少有一种类型的拉克氏裂囊肿具有独特的磁共振成像（MR）表现，具体而言，相对于白质，在T1加权图像上呈高信号，在T2加权图像上呈等信号至低信号。为了阐明囊肿内容物对MR图像的影响，我们在手术切除后通过生物医学方法分析了囊肿内容物。
我们研究了5例被诊断为拉克氏裂囊肿的患者，其MR图像在T1加权图像上呈高信号，在T2加权图像上呈等信号至低信号。手术后，对总蛋白和胆固醇水平进行定量，并在体外进行蛋白和胆固醇含量与T1和T2信号强度的相关性分析。
所有5个囊肿的蛋白浓度都非常高（11,700 - 26,600 mg/dl，平均17,940 mg/dl），几乎不含胆固醇（最多2.0 mg/dl）。随着体外蛋白浓度的增加，T1加权图像的信号强度增加，而T2加权图像的信号强度降低。相比之下，胆固醇浓度序列对T1加权图像和T2加权图像的信号强度均无影响。
拉克氏裂囊肿独特的MR表现——T1加权图像上高信号强度和T2加权图像上低信号强度——可能主要取决于蛋白浓度，而非胆固醇。
