Pillutla R C, Shimamoto A, Furuichi Y, Shatkin A J
Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey 08854-5638, USA.
Genomics. 1999 Mar 1;56(2):217-20. doi: 10.1006/geno.1998.5705.
Human p21/SIIR is a novel Ser/Arg/Pro-rich nuclear phosphoprotein that is 48% similar to transcription factor SII and modulates transcription in a promoter context-dependent fashion. We have obtained the complete sequence of TCEAL1, the gene that codes for p21/SIIR. This gene consists of three exons and two introns with the entire coding sequence in exon III. Tissue-specific expression patterns of TCEAL1 by Northern blot analysis showed the presence of an approximately 1.2-kb transcript in all normal human tissues examined, and heart and skeletal muscle contained an additional transcript of approximately 7 kb. Expression was lowest in hematopoietic cells of both normal and tumor origin. TCEAL1 was mapped to human chromosome Xq22.1 by fluorescence in situ hybridization.
