Antonangeli L, Leoli F, Maccherini D, Aghini-Lombardi F
Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Università degli Studi, Pisa.
Ann Ist Super Sanita. 1998;34(3):399-402.
In the present study, the thyroid volume of children residing in an area (Val Tiberina in Tuscany) characterized by moderate iodine deficiency in the past, was evaluated after iodized salt prophylaxis. In children born before the institution of iodine prophylaxis, thyroid volume was significantly higher than that in controls, both considering the entire population and only the nongoitrous children. In children born after iodine prophylaxis, no difference in thyroid volume was found with respect to controls. The data of the present study indicate that the exposure to iodine deficiency causes an enlargement of thyroid volume in schoolchildren. The iodized salt prophylaxis is able to prevent the development of goiter in the children born after prophylaxis and to keep the further increase of thyroid volume in older children.
在本研究中，对居住在过去曾存在中度碘缺乏地区（托斯卡纳的台伯河谷）的儿童在实施碘盐预防措施后进行了甲状腺体积评估。在碘预防措施实施之前出生的儿童中，无论是考虑全体人群还是仅考虑无甲状腺肿的儿童，其甲状腺体积均显著高于对照组。在碘预防措施实施之后出生的儿童中，未发现甲状腺体积与对照组存在差异。本研究数据表明，碘缺乏暴露会导致学龄儿童甲状腺体积增大。碘盐预防措施能够预防预防措施实施之后出生儿童甲状腺肿的发生，并使年龄较大儿童的甲状腺体积不再进一步增大。
