Turoldo A, Balani A, Tonello C, Ziza F, Roseano M
Istituto di Clinica Chirurgica Generale e Terapia Chirurgica dell'Università degli Studi di Trieste.
Ann Ital Chir. 1998 Sep-Oct;69(5):639-44; discussion 645-6.
Colorectal malignant tumors with a mono o multivisceral involvement have a poor prognosis and surgery is the only treatment with a hope to be curative. Aggressive surgical management of locally advanced colo-rectal cancer seems to be justified by good oncological results. At the Institute of Clinica Chirurgica of the University of Trieste 58 extended resections were performed for advanced tumors of colon and rectum. The specific morbidity rate was 24% for standard and 24.1% for extended resections. Operative morality was 15.2%; hystological specimen confirmed in 31 cases neoplastic infiltration of contigous structures. The 5 year survival rate was 38.5% in right colonic tumors and 53.3% in left colonic tumors. The literature favors an aggressive approach when the tumor adhesions are suspected. The excision of adjacent organs, whether or not they are microscopically involved by the tumor, is necessary to avoid leaving potentially curable disease The authors, analyzing their results, have also reported good results by management including resection of the colon and contigous organs if involved. Palliative therapy must be performed only if liver metastases are detected or in those cases when primary resection is not thecnically feable or in patients not able to tolerate the procedure.
伴有单脏器或多脏器受累的结直肠恶性肿瘤预后较差,手术是唯一有望治愈的治疗方法。局部晚期结直肠癌积极的手术治疗似乎因其良好的肿瘤学效果而合理。在的里雅斯特大学临床外科学研究所,对晚期结肠和直肠癌进行了58例扩大切除术。标准切除术的特定发病率为24%,扩大切除术为24.1%。手术死亡率为15.2%;组织学标本证实31例存在相邻结构的肿瘤浸润。右半结肠肿瘤的5年生存率为38.5%,左半结肠肿瘤为53.3%。当怀疑有肿瘤粘连时,文献支持积极的治疗方法。切除相邻器官,无论它们是否在显微镜下被肿瘤累及,对于避免留下潜在可治愈的疾病是必要的。作者在分析他们的结果时也报告了包括切除受累的结肠和相邻器官在内的治疗方法取得了良好的效果。仅当检测到肝转移时,或在初次切除在技术上不可行或患者无法耐受手术的情况下,才必须进行姑息治疗。