Jalal S, Khan K A, Alai M S, Jan V, Iqbal K, Tramboo N A, Rather H A, Lone N A, Dar M A
Department of Cardiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar.
Indian Heart J. 1998 Sep-Oct;50(5):516-9.
Four hundred and sixty-six patients (277 males, 189 females; mean age 23.2 years) diagnosed as cases of infective endocarditis during the past 15 years were retrospectively analysed. Two-thirds of patients belonged to the 15 to 35 years age group. The most common predisposing cardiac lesion was rheumatic heart disease seen in 73.4 percent patients. Mitral valve prolapse and right-sided endocarditis were infrequent, seen in four patients each. Blood culture positivity was 28.7 percent in adults and 61 percent in children. Commonest organism isolated was staphylococcus aureus in adults (39.3%) and streptococcus viridans in children (48%). Salmonella typhi was detected in 17 patients and showed excellent response to ciprofloxacin and gentamycin. Overall mortality was 13.9 percent and resistant heart failure was the leading cause of death. Our study presents the clinical spectrum of infective endocarditis and highlights the comparison with western studies.
对过去15年中诊断为感染性心内膜炎的466例患者（男性277例，女性189例；平均年龄23.2岁）进行了回顾性分析。三分之二的患者年龄在15至35岁之间。最常见的易患心脏病变是风湿性心脏病，见于73.4%的患者。二尖瓣脱垂和右侧心内膜炎较少见，各有4例患者。成人血培养阳性率为28.7%，儿童为61%。成人分离出的最常见病原体是金黄色葡萄球菌（39.3%），儿童是草绿色链球菌（48%）。在17例患者中检测到伤寒沙门菌，其对环丙沙星和庆大霉素表现出良好反应。总死亡率为13.9%，难治性心力衰竭是主要死因。我们的研究展示了感染性心内膜炎的临床谱，并突出了与西方研究的比较。
