Hori H, Ishimatsu S, Oyabu T, Yamato H, Morimoto Y, Tsuda T, Higashi T, Tanaka I
School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan.
Ind Health. 1999 Jan;37(1):103-7. doi: 10.2486/indhealth.37.103.
A clearance model of inhaled man-made fibers (MMFs) was developed, and the calculated fiber numbers and dimensions were compared with the experimental ones using a glass fiber (GF), ceramic fiber (RF1) and two potassium octatitanate whiskers (PT1, TW). If the translocation rate by macrophages is constant and the effect of dissolution and disintegration can be ignored, the fiber number is expected to decrease exponentially with time. In the experimental study, however, the fiber number did not always decrease exponentially. In the case of RF1, the fiber number decreased almost exponentially and the diameter decreased linearly with the time. The clearance rate constant of GF during 3 to 6 months after the end of one-month exposure was greater than that during 1 to 3 months. On the contrary, the clearance rate constants of PT1 and TW during 1 to 6 months were greater than next six months. The diameter and the length of GF did not change significantly. The fiber length of PT1 tends to become longer with time although the diameter did not change significantly. Our theoretical model gives a satisfactory fit to these experimental results.
建立了吸入人造纤维（MMF）的清除模型，并将计算得到的纤维数量和尺寸与使用玻璃纤维（GF）、陶瓷纤维（RF1）和两种钛酸钾晶须（PT1、TW）的实验结果进行了比较。如果巨噬细胞的转运速率恒定且溶解和崩解的影响可以忽略不计，则纤维数量预计会随时间呈指数下降。然而，在实验研究中，纤维数量并非总是呈指数下降。对于RF1，纤维数量几乎呈指数下降，直径随时间呈线性下降。在为期1个月的暴露结束后的3至6个月内，GF的清除率常数大于1至3个月期间的清除率常数。相反，PT1和TW在1至6个月期间的清除率常数大于接下来的6个月。GF的直径和长度没有明显变化。PT1的纤维长度虽直径无明显变化，但随时间有变长的趋势。我们的理论模型与这些实验结果拟合良好。
