Mehta A A, Patel S, Santani D D, Goyal R K
Department of Pharmacology, L.M. College of Pharmacy, Ahmedabad, India.
Clin Exp Hypertens. 1999 Jan-Feb;21(1-2):51-9. doi: 10.3109/10641969909068648.
Hypertension and diabetes mellitus are associated with hyperinsulinemia and insulin resistance. The present work was undertaken to study the effects of enalapril and nifedipine on insulin sensitivity in spontaneously hypertensive (SH) rats and diabetic rats. Insulin sensitivity was measured by insulin tolerance test using K(ITT) as an index of insulin mediated glucose metabolism. The time to produce 50% fall in initial blood sugar level (T1/2) was significantly higher in non-insulin dependent diabetes mellitus (NIDDM) and SH rats as compared to Wistar control. The mean K(ITT) values were significantly lower in NIDDM and SH rats as compared to Wistar control. Treatment with nifedipine (10 mg/kg) and enalapril (5 mg/kg) for 15 days produced a significant reduction in T1/2. Further, K(ITT) value was found to be significantly increased in SH rats treated with nifedipine or enalapril as compared to control. Our data indicate that NIDDM and SH rats are not only hyperinsulinemic but also insulin resistant. Nifedipine and enalapril treatment produced increase in insulin sensitivity in these animals.
高血压和糖尿病与高胰岛素血症及胰岛素抵抗相关。本研究旨在探讨依那普利和硝苯地平对自发性高血压（SH）大鼠及糖尿病大鼠胰岛素敏感性的影响。采用胰岛素耐量试验（ITT），以K（ITT）作为胰岛素介导的葡萄糖代谢指标来测定胰岛素敏感性。与Wistar对照相比，非胰岛素依赖型糖尿病（NIDDM）大鼠和SH大鼠使初始血糖水平下降50%所需的时间（T1/2）显著延长。与Wistar对照相比，NIDDM大鼠和SH大鼠的平均K（ITT）值显著降低。硝苯地平（10 mg/kg）和依那普利（5 mg/kg）治疗15天可使T1/2显著缩短。此外，与对照组相比，用硝苯地平或依那普利治疗的SH大鼠的K（ITT）值显著升高。我们的数据表明，NIDDM大鼠和SH大鼠不仅存在高胰岛素血症，而且存在胰岛素抵抗。硝苯地平和依那普利治疗可提高这些动物的胰岛素敏感性。
