Finn A M, Finn C, Sadée W
Res Commun Chem Pathol Pharmacol. 1976 Dec;15(4):613-25.
Two new major metabolites of canrenoate-potassium (III) were isolated from rabbit livers, in addition to the known metabolite canrenone (II). One metabolite (MA) contains two additional oxygen atoms of unknown location. The second metabolite (MB), which was previously shown to interfere with a plasma aldosterone radioimmunoassay, is identified as 20-hydroxy canrenone. Canrenone (II) and metabolite MB showed significant affinity to rat kidney cytosol aldosterone receptors and might both contribute to the pharmacological effects of canrenoate-K (III).
除了已知的代谢产物坎利酮（II）外，从兔肝脏中分离出了坎利酸钾（III）的两种新的主要代谢产物。一种代谢产物（MA）含有另外两个位置未知的氧原子。第二种代谢产物（MB），先前已证明其会干扰血浆醛固酮放射免疫测定，被鉴定为20-羟基坎利酮。坎利酮（II）和代谢产物MB对大鼠肾脏胞质醛固酮受体表现出显著亲和力，并且可能都对坎利酸钾（III）的药理作用有贡献。
