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[清醒动物和人的血流研究。II. 大鼠肠道水吸收进入门静脉血的机制研究(作者译)]

[Investigations in streaming blood of the alert animal and man. II. Investigations on the mechanism of water resorption from the gut into the portal vein blood in the rat (author's transl)].

作者信息

Aziz O, Sommer E

出版信息

Res Exp Med (Berl). 1976 Nov 25;169(1):45-67. doi: 10.1007/BF01851339.

Abstract

Arteriovenous differences (AVD) of electrolyte concentration in the gut are followed by continuous conductometry of ultrafiltrates of portal venous and aortic blood. Intraduodenal application of tap water amounting to 0.5, 1,0 or 2,0% body weight lead to extremely variable reactions both in time course and dimension of AVD. Whereas large and fast changes can be described by a single exponential term, small and slow changes show saturation effects. Evidence is presented, that these differences correspond to permeability changes, both for water in the direction: lumen to blood and for electrolytes in the direction: blood to lumen. Thirst has an enhancing effect on AVD. A dual resorptive pathway is proposed to fit the data.

摘要

通过对门静脉和主动脉血超滤液进行连续电导测定来追踪肠道中电解质浓度的动静脉差异(AVD)。十二指肠内给予相当于体重0.5%、1.0%或2.0%的自来水,会导致AVD在时间进程和幅度上出现极大的可变反应。虽然大而快速的变化可用单个指数项描述,但小而缓慢的变化则表现出饱和效应。有证据表明,这些差异对应于通透性变化,包括水从肠腔到血液方向以及电解质从血液到肠腔方向的通透性变化。口渴对AVD有增强作用。提出了一种双重吸收途径来拟合这些数据。

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