Solhaug J H, Glück E
Scand J Gastroenterol. 1976;11(8):793-800.
Liver biopsies of 6 patients were obtained at time of jejuno-ileal bypass and compared with liver biopsies obtained at 6, 12, and 18 months after the operation. The extent of fatty changes, cellular infiltration, connective tissue infiltration, and parenchymal cell damage was recorded. In biopsies taken 6 and 12 months postoperatively a considerable increase was observed in steatosis and cell damage, biopsies obtained at 18 months after the operation showing reduction or clearing of fat. Transient increase in periportal cell infiltration was observed, and in one patient a manifest cirrhosis developed, necessitating partial reversal of the shunt. An attempt was made to correlate the histological changes with alterations in standard liver function tests. The tests were of limited value in predicting the histological changes unless the morphological changes were very serious and the liver in a state of insufficiency. The importance of liver biopsies in the follow-up of bypass patients is stressed.
在空肠回肠分流术时获取了6例患者的肝脏活检样本，并与术后6个月、12个月和18个月获取的肝脏活检样本进行比较。记录了脂肪变性、细胞浸润、结缔组织浸润和实质细胞损伤的程度。术后6个月和12个月获取的活检样本中，脂肪变性和细胞损伤显著增加，而术后18个月获取的活检样本显示脂肪减少或消退。观察到门周细胞浸润短暂增加，1例患者发生明显肝硬化，需要部分逆转分流。试图将组织学变化与标准肝功能检查的改变相关联。除非形态学变化非常严重且肝脏处于功能不全状态，这些检查在预测组织学变化方面价值有限。强调了肝脏活检在分流患者随访中的重要性。
