Shevchenko O P, Gasilin V S
Kardiologiia. 1978 Sep;18(9):84-9.
The effect of nitroglycerin, digoxin and inderal on myocardial asynergy was studied in 108 patients with ischemic heart disease by means of echocardiography. The effect of nitroglycerin was studied in 32 patients; myocardial contractions were restored in the areas of asynergy in 15 patients, in 17 the character of myocardial asynergy did not change. The effect of digoxin was studied in 42 patients; intensification of myocardial contractions in the asynergic areas was noted in 18 patients in 16 the character of asynergy of the myocardium did not change, and in 8 paradoxical protrusion of the cardiac wall increased. Prescription of inderal for 34 patients did not lead to the development of additional areas of myocardial asynergy; proportionate decrease of the amplitude of the systolic myocardial movement in healthy areas and in areas with hypo-and dyskinesia was noted in such cases. The study showed changeability of the character of myocardial asynergy under the effect of the drugs investigated, which should be taken into account when these drugs are given to patients with ischemic heart disease.
通过超声心动图研究了硝酸甘油、地高辛和心得安对108例缺血性心脏病患者心肌协同失调的影响。对32例患者研究了硝酸甘油的作用；15例患者协同失调区域的心肌收缩得以恢复，17例患者心肌协同失调的特征未改变。对42例患者研究了地高辛的作用；18例患者协同失调区域的心肌收缩增强，16例患者心肌协同失调的特征未改变，8例患者心脏壁出现矛盾性突出。对34例患者使用心得安未导致额外的心肌协同失调区域出现；在此类病例中，观察到健康区域以及运动减弱和运动障碍区域的心肌收缩期运动幅度成比例降低。研究表明，在所研究药物的作用下，心肌协同失调的特征具有可变性，在给缺血性心脏病患者使用这些药物时应予以考虑。
