Isaacson D J, Antonelli P J
Department of Otolaryngology-Head and Neck Surgery, University of Florida College of Medicine, Gainesville, USA.
Otolaryngol Head Neck Surg. 1999 Mar;120(3):394-9. doi: 10.1016/S0194-5998(99)70282-2.
To evaluate the auditory effects of single, double, and triple semicircular canal fenestration procedures, with and without sealing the labyrinthine defect.
Violation of the inner ear remains a feared complication in otologic surgery because it commonly leads to profound sensorineural hearing loss. It has been assumed that the natural history of labyrinthine injury in the guinea pig is similar to that in human beings; however, this assumption has not been rigorously studied.
Prospective, randomized, and controlled animal study.
Sixty pigmented guinea pigs.
Click-evoked electrocochleographic response, with same-ear prefenestration control.
All of the fenestration groups had elevated auditory thresholds at 1 hour when compared with controls (P < 0.01); however, this difference lost statistical significance at 1 and 4 weeks. The degree of labyrinthine injury did not correlate with the degree of hearing loss or with the incidence of anacusis. Hearing remained stable during the study period. Sealing the fenestration had no significant audiologic effect (P > 0.40).
The guinea pig model of labyrinthine fenestration may not be representative of the human condition.
评估单、双和三半规管开窗手术在封闭或不封闭迷路缺损情况下的听觉效果。
内耳损伤仍是耳科手术中令人担忧的并发症，因为它通常会导致严重的感音神经性听力损失。一般认为豚鼠迷路损伤的自然病程与人类相似；然而，这一假设尚未得到严格研究。
前瞻性、随机对照动物研究。
60只有色豚鼠。
短声诱发的耳蜗电图反应，以同一耳开窗术前结果作为对照。
与对照组相比，所有开窗组在术后1小时听觉阈值均升高（P < 0.01）；然而，这种差异在术后1周和4周时失去统计学意义。迷路损伤程度与听力损失程度或全聋发生率无关。在研究期间听力保持稳定。封闭开窗对听力没有显著影响（P > 0.40）。
豚鼠迷路开窗模型可能无法代表人类情况。
