Shinkai K, Kida H, Hisano H, Shibasaki S, Yano H, Nomura M
Dept. of Surgery, National Ureshino Hospital.
Gan To Kagaku Ryoho. 1999 Feb;26(3):329-32.
Advanced gastric, colon and esophageal cancers (n = 21) were treated with 5-FU (250 mg) modulated by CDDP (5 mg). The reductive ratio of tumor was 6/21 (28.6%). Six cases of partial response (PR) were limited with no surgical treatment and exploratory laparotomy of all cases, and the effectiveness rate was 54.5% (6/11). Few side effects, such as dysfunction of bone marrow and kidney, were noted. Even if side effects occurred, they were mild. We concluded that excellent treatment with 5-FU modulated by CDDP has markedly improved the efficacy.
对21例晚期胃癌、结肠癌和食管癌患者使用顺铂（5 mg）调节的5-氟尿嘧啶（250 mg）进行治疗。肿瘤缩小率为6/21（28.6%）。6例部分缓解（PR）患者均未接受手术治疗，所有病例均进行了剖腹探查，有效率为54.5%（6/11）。观察到很少有副作用，如骨髓和肾脏功能障碍。即使出现副作用，也很轻微。我们得出结论，顺铂调节的5-氟尿嘧啶的良好治疗显著提高了疗效。
