Orendi J M, Boer K, van Loon A M, Borleffs J C, van Oppen A C, Boucher C A
Eijkman-Winkler Laboratorium voor Microbiologie, Infectieziekten en Ontsteking, afd. Virologie, Academisch Ziekenhuis Utrecht.
Ned Tijdschr Geneeskd. 1998 Dec 12;142(50):2720-4.
Without anti-HIV treatment, mother to child HIV-I transmission occurs in 15-30% of HIV positive pregnancies. Transmission occurs mostly in the last trimester or at birth. The maternal virus load in the last trimester and around birth is strongly related to the risk of HIV transmission to the child. This risk can be reduced during pregnancy by anti-HIV treatment and in certain cases by performing a caesarean section. It is recommended to determine the plasma virus load several times during pregnancy. If the virus load is found to be high, measurement of plasma anti-HIV drug concentrations and anti-HIV drug resistance may prompt modification of the anti-HIV drug regimen with the objective of achieving maximal suppression of virus replication in the last trimester.
在未接受抗艾滋病毒治疗的情况下，15%至30%的艾滋病毒阳性孕妇会发生母婴艾滋病毒-1传播。传播主要发生在妊娠晚期或分娩时。妊娠晚期和分娩前后的母体病毒载量与艾滋病毒传播给儿童的风险密切相关。在孕期通过抗艾滋病毒治疗，在某些情况下通过剖宫产可降低这种风险。建议在孕期多次测定血浆病毒载量。如果发现病毒载量很高，测定血浆抗艾滋病毒药物浓度和抗艾滋病毒药物耐药性可能会促使调整抗艾滋病毒药物方案，目的是在妊娠晚期实现对病毒复制的最大程度抑制。
