Bloem B R, Grimbergen Y A, Roos R A
Leids Universitair Medisch Centrum, afd. Neurologie, Leiden.
Ned Tijdschr Geneeskd. 1998 Dec 26;142(52):2825-7.
Three patients with a hypokinetic-rigid syndrome, a woman aged 69 years and two men aged 62 and 67 years, were admitted because of frequent falling. In two patients Parkinson's disease was diagnosed, the third had progressive supranuclear palsy. Balance impairment and falls typically emerge late in the course of Parkinson's disease. Falls can have dramatic physical consequences, such as (hip) fractures, and often induce a fear of additional falls which further impairs mobility and social contacts. The pathophysiology of falls in Parkinson's disease is complex and appears to result from both impaired balance regulation and commonly occurring balance disturbances (due to the shuffling gait and dyskinesias). Balance impairment often responds insufficiently to pharmacological treatment. Aspecific measures such as physical therapy, walking aids and reduction of domestic hazards can reduce the number of falls. Because patients often fail to voluntarily report their falls, physicians must actively pay attention to balance impairment in Parkinson's disease.
三名患有运动减少-强直综合征的患者,一名69岁女性和两名62岁及67岁男性,因频繁跌倒入院。两名患者被诊断为帕金森病,第三名患有进行性核上性麻痹。平衡障碍和跌倒通常在帕金森病病程后期出现。跌倒可能会造成严重的身体后果,如(髋部)骨折,并且常常引发对再次跌倒的恐惧,这会进一步损害行动能力和社会交往。帕金森病患者跌倒的病理生理学很复杂,似乎是由平衡调节受损和常见的平衡障碍(由于拖步步态和运动障碍)共同导致的。平衡障碍对药物治疗的反应往往不足。物理治疗、助行器和减少家庭危险等非特异性措施可以减少跌倒次数。由于患者常常不会主动报告跌倒情况,医生必须积极关注帕金森病患者的平衡障碍。