Rabelink A J
Universitair Medisch Centrum, afd. Nefrologie en Interne Geneeskunde, Utrecht.
Ned Tijdschr Geneeskd. 1998 Dec 26;142(52):2828-30.
The Nobel Prize for Medicine and Physiology 1998 was awarded to three American pharmacologists: Robert F.Furchgott, Louis J. Ignarro and Ferrid Murad for their work on nitric oxide as a signalling molecule in the cardiovascular system. This discovery is a classical case of serendipity. NO is an endothelium-derived factor which mediates local vasodilation. It protects the vascular system against atherosclerosis by various effects on leukocytes and vascular permeability. NO appears to be a universal signalling molecule in the body, involved in the inflammatory response, apoptosis and neurotransmission. Its biochemistry is closely linked to that of oxygen radicals.
1998年诺贝尔生理学或医学奖授予了三位美国药理学家：罗伯特·F·弗奇戈特、路易斯·J·伊格纳罗和费里德·穆拉德，以表彰他们在一氧化氮作为心血管系统信号分子方面所做的工作。这一发现是一个典型的意外发现案例。一氧化氮是一种内皮衍生因子，可介导局部血管舒张。它通过对白细胞和血管通透性的多种作用来保护血管系统免受动脉粥样硬化的影响。一氧化氮似乎是体内一种普遍的信号分子，参与炎症反应、细胞凋亡和神经传递。其生物化学与氧自由基密切相关。
