Branten A J, Wetzels J F
Academisch Ziekenhuis, afd. Nierziekten, Nijmegen.
Ned Tijdschr Geneeskd. 1998 Dec 26;142(52):2832-8.
Prednisone monotherapy is the treatment of choice for patients with a nephrotic syndrome due to minimal change glomerulopathy. In adult patients treatment should be continued for at least 24 weeks. Within this period a remission of proteinuria will occur in 75 to 90% of the patients. Patients who do not respond satisfactorily to prednisone treatment can be treated with alkylating agents. Cyclophosphamide is the drug used most commonly. Prolonged treatment (> 12 weeks) is associated with a high risk of infertility. If alkylating agents cannot be used, prolonged treatment with ciclosporine is an option.
泼尼松单一疗法是微小病变性肾小球病所致肾病综合征患者的首选治疗方法。对于成年患者，治疗应持续至少24周。在此期间，75%至90%的患者蛋白尿会缓解。对泼尼松治疗反应不佳的患者可用烷化剂治疗。环磷酰胺是最常用的药物。长期治疗（>12周）会导致不育风险很高。如果不能使用烷化剂，用环孢素进行长期治疗是一种选择。
