细胞色素P450 2J亚家族及其在肝外组织中花生四烯酸生物活化中的作用。
P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues.
作者信息
Scarborough P E, Ma J, Qu W, Zeldin D C
机构信息
Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.
出版信息
Drug Metab Rev. 1999 Feb;31(1):205-34. doi: 10.1081/dmr-100101915.
Historically, there has been intense interest in P450 metabolic oxidation, peroxidation, and reduction of xenobiotics. More recently, there has been a growing appreciation for the role of P450s in the oxidation of lipophilic endobiotics, such as bile acids, fat-soluble vitamins, and eicosanoids. This review details the emerging CYP2J subfamily of P450s and their role as catalysts of arachidonic acid metabolism.
从历史上看，人们一直对细胞色素P450对外源生物活性物质的代谢氧化、过氧化和还原作用有着浓厚的兴趣。最近，人们越来越认识到细胞色素P450在亲脂性内源性生物活性物质（如胆汁酸、脂溶性维生素和类二十烷酸）氧化过程中的作用。这篇综述详细介绍了细胞色素P450新出现的CYP2J亚家族及其作为花生四烯酸代谢催化剂的作用。
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