Martínez-Pomares L, Gordon S
Sir William Dunn School of Pathology, Oxford, UK.
Immunol Lett. 1999 Jan;65(1-2):9-13. doi: 10.1016/s0165-2478(98)00117-5.
Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in follicular dendritic cells and migratory dendritic cells in immunised animals. Based on this labelling pattern and the identification of a soluble form of the MR in macrophage-conditioned media and mouse serum, we propose a novel role for this receptor in antigen transport.
利用一种Fc嵌合蛋白通过免疫组织化学方法，在未接触抗原的小鼠脾脏边缘区亲金属巨噬细胞和淋巴结被膜下窦巨噬细胞中检测到了小鼠甘露糖受体（MR）富含半胱氨酸结构域的潜在内源性配体。在免疫动物的滤泡树突状细胞和迁移树突状细胞中也观察到了额外的标记。基于这种标记模式以及在巨噬细胞条件培养基和小鼠血清中鉴定出MR的可溶性形式，我们提出该受体在抗原转运中具有新的作用。
