Filicori M
Reproductive Endocrinology Center, Department of Obstetrics and Gynecology, University of Bologna, Italy.
Fertil Steril. 1999 Mar;71(3):405-14. doi: 10.1016/s0015-0282(98)00482-8.
To review the physiologic, pathophysiologic, and clinical roles of LH in follicle and oocyte development and maturation and to assess the effects of LH content in exogenous gonadotropin preparations used for ovulation induction.
Critical review of the scientific literature devoted to folliculogenesis. Evaluation of comparison studies that used different gonadotropin preparations for ovulation induction.
CONCLUSION(S): Folliculogenesis and oocyte maturation are complex processes that require the action of both LH and FSH. Luteinizing hormone is essential to provide the androgen substrate for estrogen synthesis, which in turn contributes to oocyte maturation and may play a relevant role in optimizing fertilization and embryo quality. Although the excessive LH secretion that is present in some disorders is detrimental to reproductive function, this is not applicable to ovulation induction with hMG because this menotropin does not increase daily plasma LH levels. The results of ovulation induction with hMG or FSH-only regimens did not differ in studies conducted in patients with polycystic ovary syndrome and in most studies conducted in ovulatory women undergoing assisted reproductive techniques; conversely, hMG was clearly superior to purified FSH for the treatment of hypogonadotropic hypogonadism. Miscarriage rates were not affected by the use of hMG. Thus, low but detectable LH concentrations positively influence the outcome of ovulation induction in patients with ovulatory disorders and women undergoing assisted reproductive techniques.
综述促黄体生成素（LH）在卵泡和卵母细胞发育及成熟过程中的生理、病理生理及临床作用，并评估用于诱导排卵的外源性促性腺激素制剂中LH含量的影响。
对有关卵泡发生的科学文献进行批判性综述。对使用不同促性腺激素制剂诱导排卵的比较研究进行评估。
卵泡发生和卵母细胞成熟是复杂的过程，需要LH和促卵泡生成素（FSH）共同作用。黄体生成素对于为雌激素合成提供雄激素底物至关重要，而雌激素合成反过来又有助于卵母细胞成熟，并且可能在优化受精和胚胎质量方面发挥相关作用。虽然某些疾病中存在的LH分泌过多对生殖功能有害，但这不适用于用人绝经期促性腺激素（hMG）诱导排卵，因为这种促性腺激素不会增加每日血浆LH水平。在多囊卵巢综合征患者中进行的研究以及在接受辅助生殖技术的排卵女性中进行的大多数研究中，使用hMG或仅使用FSH的诱导排卵方案的结果没有差异；相反，hMG在治疗低促性腺激素性性腺功能减退方面明显优于纯化的FSH。流产率不受使用hMG的影响。因此，低但可检测到的LH浓度对排卵障碍患者和接受辅助生殖技术的女性的诱导排卵结果有积极影响。
