Kanakas N, Mantzavinos T, Boufidou F, Koumentakou I, Creatsas G
Second Department of Obstetrics and Gynecology, Areteion Hospital, University of Athens, Greece.
Fertil Steril. 1999 Mar;71(3):523-7. doi: 10.1016/s0015-0282(98)00472-5.
To determine the effect of the presence of Ureaplasma urealyticum in semen on IVF outcome (fertilization, pregnancy, and abortion rates).
Prospective study.
Private IVF unit in Athens, Greece.
PATIENT(S): One hundred ninety-one asymptomatic men with normal semen parameters whose wives underwent an IVF cycle.
INTERVENTION(S): Culture of semen for U. urealYticum on the day of oocyte retrieval.
MAIN OUTCOME MEASURE(S): Fertilization, pregnancy, and abortion rates after IVF.
RESULT(S): Ninety-six (86%) of the 112 women whose husbands' semen was negative for U. urealyticum and 65 (82%) of the 79 women whose husbands' semen was positive for U. urealyticum underwent ET. The pregnancy rate (PR) was 20% (19/96) in the negative group and 17% (11/65) in the positive group. An increased incidence of abortions (6/11) was observed in the positive group (abortion rate, 54%), compared with 21% (4/19) in the group of women whose husbands' semen was negative for U. urealyticum.
CONCLUSION(S): Fertilization rates and PRs may not be affected by the presence of U. urealyticum in semen on the day of oocyte retrieval. It can be presumed that the semen preparation for IVF cleanses the semen of U. urealyticum. On the other hand, the higher abortion rate in the U. urealyticum-positive group might be related to maternal factors, such as an existing U. urealyticum infection or one contracted after conception.
确定精液中解脲脲原体的存在对体外受精结局（受精率、妊娠率和流产率）的影响。
前瞻性研究。
希腊雅典的私立体外受精机构。
191名无症状且精液参数正常的男性，其妻子接受了体外受精周期。
取卵当天对精液进行解脲脲原体培养。
体外受精后的受精率、妊娠率和流产率。
丈夫精液解脲脲原体检测阴性的112名女性中有96名（86%）、丈夫精液解脲脲原体检测阳性的79名女性中有65名（82%）接受了胚胎移植。阴性组的妊娠率（PR）为20%（19/96），阳性组为17%（11/65）。阳性组观察到流产发生率增加（6/11）（流产率为54%），而丈夫精液解脲脲原体检测阴性的女性组流产率为21%（4/19）。
取卵当天精液中解脲脲原体的存在可能不会影响受精率和妊娠率。可以推测，体外受精的精液制备清除了解脲脲原体。另一方面，解脲脲原体阳性组较高的流产率可能与母体因素有关，如现有的解脲脲原体感染或受孕后感染。
