Gashlan M, Loy-English I, Ventureyra E C, Keene D
Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Childs Nerv Syst. 1999 Jan;15(1):45-50; discussion 50-1. doi: 10.1007/s003810050326.
Several preoperative clinical variables have been reported to have value as predictors of seizure outcome following the surgical resection of epileptogenic focus in adults who have had medically refractory epilepsy. The present paper reports the results of a retrospective review of the ability of these variables to predict seizure outcome in a group of pediatric patients who had medically refractory epilepsy and underwent surgical resection of an epileptogenic focus at the Children's Hospital of Eastern Ontario. Variables in this review included age at first seizure, age at time of surgery, duration of seizures, seizure type, sex, family history, etiology, level of intelligence, EEG data, results of imaging studies, findings on examination of the central nervous system, and location and site of surgical resection. We found 64 patients who met the entry criteria for this review. Normal intelligence and tumor as etiology were associated with a good postoperative seizure outcome in patients who had a temporal resection; no variables had positive correlation with outcome in the extratemporal group. Caution must be used in the extrapolation of data and inclusion of studies of predictors of seizure outcome for adults to pediatric age groups.
据报道，在药物难治性癫痫的成年患者中，几种术前临床变量对于预测癫痫病灶手术切除后的癫痫发作结果具有参考价值。本文报告了一项回顾性研究结果，该研究旨在评估这些变量对一组药物难治性癫痫且在安大略省东部儿童医院接受癫痫病灶手术切除的儿科患者癫痫发作结果的预测能力。本研究中的变量包括首次发作年龄、手术时年龄、癫痫发作持续时间、癫痫发作类型、性别、家族史、病因、智力水平、脑电图数据、影像学检查结果、中枢神经系统检查结果以及手术切除的位置和部位。我们找到了64名符合本研究纳入标准的患者。对于颞叶切除术患者，智力正常和肿瘤病因与术后癫痫发作结果良好相关；在颞叶外组中，没有变量与结果呈正相关。在将成人癫痫发作结果预测因素的数据外推至儿童年龄组以及纳入相关研究时必须谨慎。
