Sutor A H
Universitäts-Kinderklinik, Freiburg, Germany.
Semin Thromb Hemost. 1998;24(6):545-8. doi: 10.1055/s-2007-996053.
Acute immune thrombocytopenia (ITP) in children is a benign disease, presenting mostly with skin purpura and minor bleeds. It has a high rate of spontaneous remission. Intracranial hemorrhage (ICH) is extremely rare; the risk is higher during the chronic phase and in children with additional risk factors. The threshold platelet count in ITP is not known because of problems with platelet counting in thrombocytopenia and the lack of clinical data. The threshold is probably lower than in leukemia, because primary hemostasis is better in ITP. So far, there is no proof for the clinical efficacy of treatment or prophylaxis with intravenous immunoglobulin (IVIg) and glucocorticoids (GC), medications that have several adverse effects. The question remains open whether or not we are treating the platelet count in children with acute ITP.
儿童急性免疫性血小板减少症（ITP）是一种良性疾病，主要表现为皮肤紫癜和轻微出血。其自发缓解率很高。颅内出血（ICH）极为罕见；在慢性期以及伴有其他危险因素的儿童中风险更高。由于血小板减少症中血小板计数存在问题且缺乏临床数据，ITP的血小板计数阈值尚不清楚。该阈值可能低于白血病，因为ITP的初级止血功能较好。到目前为止，尚无证据表明静脉注射免疫球蛋白（IVIg）和糖皮质激素（GC）进行治疗或预防具有临床疗效，而这些药物有多种不良反应。对于急性ITP患儿，我们是否在治疗血小板计数这一问题仍未解决。
