Palmieri S J, Haarer B K
Department of Zoology, Institute for Cellular and Molecular Biology, The University of Texas, Austin, TX 78712-1064, USA.
Curr Opin Microbiol. 1998 Dec;1(6):678-86. doi: 10.1016/s1369-5274(98)80115-x.
A significant component of polarization in budding yeast involves the regulated restructuring of the actin cytoskeleton in response to defined cellular signals. Recent evidence suggests that such cytoskeletal organization arises through the action of large protein complexes that form in response to signals from small GTP-binding proteins, such as Cdc42, Rho, and Ras. These actin-organizing complexes may be fairly diverse, but generally consist of one or more central scaffold proteins, such as those of the formin class, that bind to signaling molecules and recruit actin-binding proteins to bring about desired polarizing events.
芽殖酵母中极化的一个重要组成部分涉及肌动蛋白细胞骨架响应特定细胞信号而进行的调控重组。最近的证据表明，这种细胞骨架组织是通过大型蛋白质复合物的作用形成的，这些复合物是响应来自小GTP结合蛋白（如Cdc42、Rho和Ras）的信号而形成的。这些肌动蛋白组织复合物可能相当多样，但通常由一种或多种中央支架蛋白组成，比如formin类的蛋白，它们与信号分子结合并招募肌动蛋白结合蛋白来引发所需的极化事件。
