Sanada I, Kawano F, Tsukamoto A, Kiyokawa T
Institute for Clinical Research, Kumamoto National Hospital.
Rinsho Ketsueki. 1999 Jan;40(1):51-4.
We report on two adult T-cell leukemia (ATL) patients whose levels of serum hyaluronic acid (HA) moved in parallel with the clinical activity of their disease. A 66-year-old man was admitted to our hospital because of unconsciousness and hypotension. Acute type ATL complicated by hypercalcemia and myelofibrosis was diagnosed. Before therapy, the level of patient's serum HA was 2,045 to 4,010 ng/ml (normal range: 50 >). After he achieved complete remission (CR) through chemotherapy, his serum HA was 36 ng/ml. Several months later, however, his ATL relapsed, and his serum HA increased to 393 ng/ml. The other patient was an 80-year-old man who had been admitted on the suspected diagnosis of ATL. Before chemotherapy, his serum HA was high (3,420 ng/ml). After CHOP therapy, he entered CR and his HA decreased to 122 ng/ml. He remains in CR with slightly elevated levels of HA (127 to 212 ng/ml), and is being followed up on an out-patient basis.
我们报告了两名成人T细胞白血病（ATL）患者，其血清透明质酸（HA）水平与疾病的临床活动呈平行变化。一名66岁男性因意识不清和低血压入院。诊断为急性型ATL合并高钙血症和骨髓纤维化。治疗前，患者血清HA水平为2045至4010 ng/ml（正常范围：50>）。他通过化疗实现完全缓解（CR）后，血清HA为36 ng/ml。然而，几个月后，他的ATL复发，血清HA升至393 ng/ml。另一名患者是一名80岁男性，因疑似ATL入院。化疗前，他的血清HA很高（3420 ng/ml）。CHOP治疗后，他进入CR，HA降至122 ng/ml。他仍处于CR状态，HA水平略有升高（127至212 ng/ml），正在门诊随访。
