Konermann G
Strahlentherapie. 1976 Dec;152(6):550-76.
Following daily fractionated X-irradiation in utero, a postnatal study of the mouse liver was made with regard to compensatory growth responses depending on the radiation dose and on the age of the germ while irradiated. Exposure to doses between 10 R/d and 60 R/d was performed during blastogenesis (1st to 5th day p.c.), organogenesis (6th to 13th day p.c.), fetogenesis (14th to 18th day p.c.), as well as during the early (6th to 10th day p.c.) and the late embryogenesis (11th to 15th day p.c.). Besides deviations of the increase in weight and of the nucleic acid content, the incorporation of 3H-thymidine into DNA was measured by means of scintilation counts and radioautographs. As compared with controls, all irradiated experimental groups exhibit a periodical increase of the proliferative hepatic growth especially towards the end of the first and of the second post-natal week. The possibility of inducing compensatory responses decreases, however, with increasing age of the germs, a gradation thus appearing from overcompensation effects after exposures during blastogenesis down to poor proliferation responses after irradiations in the course of fetogenesis. The dose dependence of proliferation responses after irradiations during organogenesis is characterized by an overstrain of the capacity for recovery following 60 R/d, by maximum compensatory growth after 40 R/d, and by a slight stimulation of growth following 10 R/d, in the otherwise apparently normal animals. Late proliferative responses of the developing liver are regarded as a self-stabilisation towards the predetermined norm of growth. Essential differences in comparison with a stress - or a strain - stimulated growth (as in the adult regenerating liver) are suggested by the observation that (a) cytogenesis in the functionally independent populations of blood cells and of parenchymal cells is stimulated partly at the same time and to a similar extent, (b), that stimulation effects reach a peak always within equal stages of development independent of the X-ray doses and the age at irradiation and (c) that an acceleration of growth is possible with a normal or even augmented ratio of organ-weight to body-weight.
在子宫内进行每日分次X射线照射后，对小鼠肝脏进行了产后研究，以观察取决于辐射剂量和受照时胚龄的代偿性生长反应。在胚泡形成期（妊娠第1至5天）、器官形成期（妊娠第6至13天）、胎儿形成期（妊娠第14至18天）以及胚胎发育早期（妊娠第6至10天）和晚期（妊娠第11至15天）给予10 R/d至60 R/d的剂量照射。除了体重增加和核酸含量的偏差外，还通过闪烁计数和放射自显影法测定了3H-胸腺嘧啶核苷掺入DNA的情况。与对照组相比，所有受照实验组的肝脏增殖性生长均呈现阶段性增加，尤其是在出生后第一周和第二周结束时。然而，随着胚龄的增加，诱导代偿反应的可能性降低，因此出现了从胚泡形成期受照后的过度代偿效应到胎儿形成期受照后增殖反应不佳的梯度变化。器官形成期照射后增殖反应的剂量依赖性表现为：60 R/d照射后恢复能力过度负荷，40 R/d照射后出现最大代偿性生长，10 R/d照射后生长略有刺激，而在其他方面看似正常的动物中也是如此。发育中肝脏的晚期增殖反应被视为朝着预定生长标准的自我稳定。与应激或应变刺激生长（如成年再生肝脏）相比的本质差异表现为以下观察结果：(a) 血细胞和实质细胞功能独立群体中的细胞生成部分同时且在相似程度上受到刺激，(b) 刺激效应总是在发育的相同阶段达到峰值，与X射线剂量和受照年龄无关，(c) 生长加速是可能的，且器官重量与体重的比例正常甚至增加。
