[Effects of fenigidin treatment regimen on the state of peripheral hemodynamics of patients with stable effort angina pectoris and postinfarction cardiosclerosis].

AIM

To examine the impact of fenigidin treatment regimen on peripheral hemodynamics in patients with stable angina pectoris of effort and postinfarction cardiosclerosis without signs of heart failure.

MATERIALS AND METHODS

Thirty two patients with functional classes II and III stable angina of effort and 32 with postinfarction cardiosclerosis without signs of heart failure were examined.

RESULTS

Monotherapy with fenigidin, 30-40 mg/day in patients with stable angina pectoris of effort and in those with postinfarction cardiosclerosis lowered systolic and mean blood pressures, total and specific peripheral vascular resistance, venous tone and increased additional venous volume and maximum vein emptying rate in the upper and lower extremities. Fenigidin therapy caused no side effects.

CONCLUSION

Fenigidin monotherapy improves hemodynamic parameters in stable angina pectoris of effort and postinfarction cardiosclerosis without obvious signs of heart failure and causes no side effects when the drug is used in a dose of 30-40 mg/day for 3 weeks.