Tepliakov A T, Aptekar' V D, Kalomin E Iu, Garganeeva A A, Cherniavskiĭ A M, Lusta I V, Chernov V I, Karpov R S
Ter Arkh. 1998;70(12):35-8.
The study of efficacy of rehabilitation and clinical-instrumental characteristics of coronary failure in patients with ischemic heart disease (IHD) of high functional classes and moderate dyslipoproteinemia early (1.6 months) and late (1 and 3 years) after coronary by-pass operation.
The examination covered 119 males with IHD (mean age 51.8 +/- 6.9 years) 1.6 months and 3 years after coronary by-pass operation. Lipid spectrum of blood plasma, frequency of anginal attacks, 24-h nitroglycerin requirement, results of bicycle exercise and loading myocardial scintigraphy were assessed. The patients were divided into two groups. In 82 patients of group 1 total cholesterol ranged within 3 years after the surgery from 5.2 to 6.5 mmol/l, 37 patients of group 2 had no lipid disorders.
Within 12 months after direct myocardial revascularization, the groups had similar clinical-instrumental characteristics. 3 years after the operation, patients of group 1 exhibited a rise in anginal attacks frequency, nitroglycerin requirement, size of unstable perfusion defects by 84.6, 88.8 and 26.4%, respectively. Exercise tolerance diminished by 18.7%.
Moderate defects in lipid metabolism influence progression of coronary failure. This becomes especially pronounced within 3 years after coronary by-pass operation.
研究冠状动脉搭桥术后早期（1.6个月）和晚期（1年及3年），高功能分级和中度血脂异常的缺血性心脏病（IHD）患者冠状动脉衰竭的康复疗效及临床仪器特征。
对119例IHD男性患者（平均年龄51.8±6.9岁）进行冠状动脉搭桥术后1.6个月及3年的检查。评估血浆脂质谱、心绞痛发作频率、24小时硝酸甘油需求量、自行车运动结果及负荷心肌闪烁扫描结果。患者分为两组。第1组82例患者术后3年内总胆固醇范围为5.2至6.5 mmol/l，第2组37例患者无脂质紊乱。
直接心肌血运重建术后12个月内，两组临床仪器特征相似。术后3年，第1组患者心绞痛发作频率、硝酸甘油需求量、不稳定灌注缺损大小分别增加84.6%、88.8%和26.4%。运动耐量降低18.7%。
脂质代谢的中度缺陷影响冠状动脉衰竭的进展。这在冠状动脉搭桥术后3年内尤为明显。
