Zaslavskaia R M, Komarov F I, Goncharov L F, Goncharova Z F, Makarova L A
Klin Med (Mosk). 1998;76(12):49-51.
Effectiveness of Cozaar monotherapy (50 mg at 8 a.m.) was compared to that of Cozaar combination with melatonin (3 mg before sleep) in 21 patients with hypertension stage II (mean age 62 years). Clinical symptoms and hemodynamic parameters were evaluated with ECG and blood pressure monitoring. The findings were processed with statistical methods and Kosinor-analysis. Cozaar alone had moderate hypotensive and vasodilating effects, affected circadian rhythm of systolic and diastolic blood pressure, heart rate. Combination Cozaar + melatonin reduced blood pressure more noticeably, diminished cardiac output, energy consumption of the myocardium, normalized normal chronostructure of blood pressure and heart rate circadian rhythms.
将科素亚单药治疗（上午8点服用50毫克）与科素亚联合褪黑素（睡前服用3毫克）对21例II期高血压患者（平均年龄62岁）的疗效进行了比较。通过心电图和血压监测评估临床症状和血流动力学参数。采用统计方法和科索诺尔分析对结果进行处理。单独使用科素亚有中度降压和血管舒张作用，影响收缩压和舒张压的昼夜节律以及心率。科素亚 + 褪黑素联合用药能更显著地降低血压，减少心输出量、心肌能量消耗，使血压和心率的昼夜节律正常时间结构恢复正常。
