非洲糙皮病（烟酸和色氨酸缺乏）患者的D-木糖吸收及空肠形态

D-xylose absorption and jejunal morphology in African patients with pellagra (niacin tryptophan deficiency).

作者信息

Cook G C

出版信息

Trans R Soc Trop Med Hyg. 1976;70(4):349-51. doi: 10.1016/0035-9203(76)90098-5.

Abstract

D-xylose absorption tests and jejunal morphology have been shown to be unaltered in 12 African patients with pellagra when compared with normal values for Zambian Africa adults; that result is contrary to two previous investigations in India and Egypt respectively. A significant inverse association has been shown, however, between D-xylose absorption and serum immunoglobulin IgG and IgA concentrations; that is consistent with previous studies and probably reflects malabsorption of xylose in the presence of systemic infections. It is concluded that pellagra per se does not alter intestinal structure or monosaccharide absorption.

摘要

与赞比亚成年非洲人正常值相比，12例非洲糙皮病患者的D-木糖吸收试验和空肠形态未发生改变；该结果与之前分别在印度和埃及进行的两项研究相反。然而，已表明D-木糖吸收与血清免疫球蛋白IgG和IgA浓度之间存在显著的负相关；这与之前的研究一致，可能反映了在全身性感染情况下木糖的吸收不良。得出的结论是，糙皮病本身不会改变肠道结构或单糖吸收。