Licata A, Mauceri A, Ainis L, Martella S, Ricca M B, Lauriano E R, Amato A
Department of Animal Biology and Marine Ecology, University of Messina, Faculty of Science, Italy.
Eur J Histochem. 1998;42(4):303-8.
Serotonin (5HT), endothelin-big (ET-big) and neuron-specific enolase (NSE) are present in some epithelial paraneuronal cells of vertebrates. In the invertebrates, we show for the first time, by immunofluorescence and immunoperoxidase methods, the immunoreactions to antibodies raised to ET, 5-HT and NSE in the epidermis of the Lumbricus terrestris. It is assumed that the reactive cells are small granular cells that may have a paracrine action in the mechanisms of cell proliferation and secretory processes. The function of these bioactive substances in the epidermis of the earthworm awaits investigation. Phylogenetically it is very interesting that paraneuronal-like type of cells appear in such an ancient species of invertebrate which uses the epidermis for various functional activities.
血清素（5-羟色胺，5HT）、大内皮素（ET-big）和神经元特异性烯醇化酶（NSE）存在于脊椎动物的一些上皮旁神经元细胞中。在无脊椎动物中，我们首次通过免疫荧光和免疫过氧化物酶方法，展示了在蚯蚓表皮中对针对ET、5-HT和NSE产生的抗体的免疫反应。据推测，反应性细胞是小颗粒细胞，它们可能在细胞增殖和分泌过程机制中具有旁分泌作用。这些生物活性物质在蚯蚓表皮中的功能有待研究。从系统发育角度来看，非常有趣的是，类似旁神经元类型的细胞出现在这样一种古老的无脊椎动物物种中，该物种利用表皮进行各种功能活动。
