Ziecina R, Abramczyk P, Lisiecka A, Papierski K, Przybylski J
Department of Human Physiology, Medical University of Warsaw, Poland.
J Physiol Pharmacol. 1998 Dec;49(4):553-60.
The aim of the present study was to investigate a role of adrenal-renal portal circulation (ARPC) in a decrease in renal blood flow due to acute stenosis of the renal artery in rats. Animals were divided into three groups. In the control group (I), in order to eliminate the ARPC tissue between the adrenal gland and the ipsilateral kidney was cut. In the second and the third group (II) (III), left renal artery was stenosed by a silver clip (ID 0.40 mm). Then, in the group II, ARPC was surgically eliminated. In the group II, prior to the elimination of ARPC, alpha-adrenergic receptors blockade was produced by phentolamine administration. In the control group, ARPC elimination did not influence either renal blood flow (RBF) or renal vascular resistance (RVR). In the group II, elimination of ARPC caused increase in RBF and decrease in RVR In the group III elimination of ARPC influenced neither RBF nor renal vascular resistance (RVR). Results of the present study provide the functional evidence that catecholamines reaching the kidney through ARPC, contribute to the decrease in RBF and increase in RVR during acute renal artery stenosis in the rat.
本研究的目的是探讨肾上腺 - 肾门静脉循环（ARPC）在大鼠肾动脉急性狭窄导致肾血流量减少中的作用。动物被分为三组。在对照组（I）中，为消除肾上腺与同侧肾脏之间的ARPC组织，将其切断。在第二组和第三组（II）（III）中，用银夹（内径0.40 mm）使左肾动脉狭窄。然后，在第二组中，通过手术消除ARPC。在第二组中，在消除ARPC之前，通过给予酚妥拉明产生α - 肾上腺素能受体阻滞。在对照组中，消除ARPC对肾血流量（RBF）或肾血管阻力（RVR）均无影响。在第二组中，消除ARPC导致RBF增加和RVR降低。在第三组中，消除ARPC对RBF和肾血管阻力（RVR）均无影响。本研究结果提供了功能证据，即通过ARPC到达肾脏的儿茶酚胺在大鼠急性肾动脉狭窄期间有助于RBF减少和RVR增加。
