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Pros and cons of the use of antihistamines in managing allergic rhinitis.

作者信息

Day J

机构信息

Division of Allergy and Immunology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.

出版信息

J Allergy Clin Immunol. 1999 Mar;103(3 Pt 2):S395-9. doi: 10.1016/s0091-6749(99)70219-8.

DOI:10.1016/s0091-6749(99)70219-8
PMID:10069900
Abstract

Histamine H1 -receptor antagonists are generally considered first-line therapy for the management of allergic rhinitis. Other than histamine antagonism, several of the second-generation antihistamines have also shown inhibitory effects on chemical mediators of inflammation such as leukotrienes, prostaglandins, and kinins. This article reviews the pharmacology, clinical use, and side effect profiles of the commonly used H1 -receptor antagonists.

摘要

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