Kumar R
Department of Neurosurgery, Sanjay Gandhi Institute of Medical Sciences, Lucknow, India.
Br J Neurosurg. 1998 Aug;12(4):344-8. doi: 10.1080/02688699844862.
Five cases of intracranial tuberculosis with atypical response to antitubercular chemotherapy are reported. In these cases tuberculomas either increased in sizes or first developed during course of adequate chemotherapy for tubercular meningitis or postmeningitic hydrocephalus. In two of these cases granulomas were located deeply in the parenchyma; however, these were on the surface in the other three. Atypical response to antitubercular treatment was observed at 5 weeks, 8 weeks, 2 months (in two cases) and 6 months. Glucocorticoid therapy was instituted in two cases and surgical excision of tuberculomas performed in the others. Recovery was good in all the five cases excluding visual loss, which remained unchanged in two cases because of prexisting secondary optic atrophy.
报告了5例颅内结核对抗结核化疗反应不典型的病例。在这些病例中，结核瘤要么体积增大，要么在结核性脑膜炎或脑膜炎后脑积水的充分化疗过程中首次出现。其中2例肉芽肿位于脑实质深部；然而，另外3例位于表面。在5周、8周、2个月（2例）和6个月时观察到对抗结核治疗的不典型反应。2例采用糖皮质激素治疗，其他病例进行了结核瘤手术切除。除2例因原有继发性视神经萎缩视力无变化外，其余5例恢复良好。
