Braun U, Linggi T, Pospischil A
Clinic of Veterinary Internal Medicine, Zurich, Switzerland.
Vet Rec. 1999 Jan 30;144(5):122-6. doi: 10.1136/vr.144.5.122.
Three cows with regwort (Senecio alpinus) poisoning were examined clinically, haematologically and ultrasonographically, and biopsy specimens of the liver were examined histologically. At the end of the study, the cows were euthanased and examined postmortem. The major clinical signs included severely disturbed general demeanour and behaviour, and severe diarrhoea. One cow was photosensitive. The activities of liver enzymes and the concentration of bilirubin were high in all of the cows. In two of the cows, ultrasonographic examination revealed a heavy accumulation of abdominal fluid, which was diagnosed as non-inflammatory ascites. In all the cows, the liver parenchyma was heterogeneous, and cows 1 and 2 had multiple echogenic foci 5 to 10 mm in diameter. In cow 3, the facies diaphragmatica of the liver appeared irregular in outline owing to the presence of nodules which were approximately 5 cm in diameter. The liver was also greatly enlarged and extended almost to the linea alba ventrally and beyond the reticulum cranially. All the cows had portal hypertension and the portal vein was dilated, resulting in oedema of the walls of the gall bladder, the small intestines and the omentum. The diameter of the caudal vena cava was reduced as a result of the impaired hepatic circulation. Histological examination of liver biopsy specimens revealed severe hepatic fibrosis in all the cows.
对三头患有千里光（高山千里光）中毒的奶牛进行了临床、血液学和超声检查，并对肝脏活检标本进行了组织学检查。研究结束时，对奶牛实施安乐死并进行了尸体剖检。主要临床症状包括严重的全身行为举止紊乱和严重腹泻。有一头奶牛出现光敏反应。所有奶牛的肝酶活性和胆红素浓度均升高。其中两头奶牛的超声检查显示腹腔内有大量积液，诊断为非炎性腹水。所有奶牛的肝实质均不均匀，1号和2号奶牛有多个直径为5至10毫米的高回声灶。在3号奶牛中，由于存在直径约5厘米的结节，肝脏的膈面轮廓显得不规则。肝脏也明显肿大，腹侧几乎延伸至白线，头侧超出网胃。所有奶牛均有门静脉高压，门静脉扩张，导致胆囊壁、小肠和网膜水肿。由于肝循环受损，尾腔静脉直径减小。肝脏活检标本的组织学检查显示，所有奶牛均有严重的肝纤维化。
