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[类风湿关节炎中骨丢失的测量]

[Measure of bone loss in rheumatoid arthritis].

作者信息

Náfrádi L, Toldy E, Varga L

机构信息

Reumatológiai Osztály, Vas Megyei Markusovszky Kórház, Szombathely.

出版信息

Orv Hetil. 1999 Feb 7;140(6):281-4.

Abstract

The authors examined the degree of bone loss by single photon osteodensitometry in 72 patients with rheumatoid arthritis (RA). A control group was set up consisting of osteoarthritis patients of the same age and gender. As a result of the osteodensitometrical examination osteopenia was observed in 22-, osteoporosis in 37- and normal density in 14 rheumatoid arthritis patients. These results showed considerable difference compared to the density results of the control group (n = 72) (p < 0.001). They also analysed the role of risk factors affecting bone loss in three groups of rheumatoid arthritis patients, with osteoporosis, osteopenia and with normal density results. As risk factors the duration of the rheumatoid arthritis, the duration of the postmenopause, the age, the cumulative doses of steroid and the activity of rheumatoid arthritis were mentioned. Among risk factors the duration of the rheumatoid arthritis, the age, the duration of the postmenopause and the Steinbrocker phase classification correlated with the osteodensitometrical results. At the same time no correlation has been observed in relation to the cumulative doses of steroid and the Ritchie joint index.

摘要

作者采用单光子骨密度测定法检测了72例类风湿关节炎(RA)患者的骨质流失程度。设立了一个由年龄和性别相同的骨关节炎患者组成的对照组。骨密度检查结果显示,22例类风湿关节炎患者存在骨质减少,37例存在骨质疏松,14例骨密度正常。与对照组(n = 72)的密度结果相比,这些结果显示出显著差异(p < 0.001)。他们还分析了影响三组类风湿关节炎患者骨质流失的危险因素的作用,这三组患者分别存在骨质疏松、骨质减少以及骨密度正常。作为危险因素,提到了类风湿关节炎的病程、绝经后持续时间、年龄、类固醇累积剂量以及类风湿关节炎的活动度。在危险因素中,类风湿关节炎的病程、年龄、绝经后持续时间以及斯坦布鲁克分期与骨密度测定结果相关。同时,未观察到类固醇累积剂量与里奇关节指数之间存在相关性。

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