Bigam D, Zhong R, Levy G, Grant D
Department of Surgery, University of Western Ontario, London.
Can J Surg. 1999 Feb;42(1):12-6.
As transplantation waiting lists lengthen because of the shortage of donor organs, the death rates of patients continue to rise. Xenotransplantation offers the potential to solve the problem of organ shortage br providing an unlimited supply of healthy donor organs. However, there are several barriers to xenotransplantation, including graft rejection, potential xenozoonosis, physiologic incompatibilities and ethical concerns. Experimental xenotransplantation studies continue in several areas, ranging from tissue to whole- organ grafting. Clinical studies continue in the area of tissue xenotransplantation. Trials with extracorporeal xenografts in an acute setting to support fulminant organ failure are likely to begin in the near future. The reintroduction of whole-organ xenotransplantation must be based on sound scientific analysis with broad societal input so as to offer the maximal benefit to transplant recipients and their families.
由于供体器官短缺，移植等待名单不断延长，患者死亡率持续上升。异种移植通过提供无限供应的健康供体器官，有望解决器官短缺问题。然而，异种移植存在若干障碍，包括移植物排斥、潜在的异种动物传染病、生理不相容性和伦理问题。从组织移植到全器官移植，多个领域都在继续进行异种移植实验研究。组织异种移植领域也在继续开展临床研究。在急性情况下使用体外异种移植物支持暴发性器官衰竭的试验可能在不久的将来开始。全器官异种移植的重新引入必须基于合理的科学分析并得到广泛的社会参与，以便为移植受者及其家庭带来最大利益。
