阿尔茨海默病患者血清中的抗小胶质细胞抗体。
Antimicroglia antibodies in sera of Alzheimer's disease patients.
作者信息
Lemke M R, Glatzel M, Henneberg A E
机构信息
Department of Psychiatry, University of Kiel, Germany.
出版信息
Biol Psychiatry. 1999 Feb 15;45(4):508-11. doi: 10.1016/s0006-3223(97)00456-3.
BACKGROUND
Immune mechanisms seem to contribute to the degenerative process in Alzheimer's disease. Antibodies directed against animal brain tissue were found in sera of Alzheimer's patients.
METHODS
Antibodies were measured in sera of 25 Alzheimer's patients and a comparison group of 25 age- and sex-matched controls. Sera were tested for their immunological response to various brain structures of postmortem human brain tissue.
RESULTS
In 8 patients with Alzheimer's disease perinuclear antibodies directed against microglia were found in amygdala and frontal cortex. In the control group 1 subject showed antibody binding to microglia.
CONCLUSIONS
Perinuclear antibodies to microglia may play a role in tissue destruction of Alzheimer's disease. These data add to the evidence that immune mechanisms play a role in the pathophysiology of Alzheimer's disease.
背景
免疫机制似乎在阿尔茨海默病的退行性病变过程中发挥作用。在阿尔茨海默病患者的血清中发现了针对动物脑组织的抗体。
方法
检测了25例阿尔茨海默病患者以及25例年龄和性别匹配的对照组的血清中的抗体。检测血清对死后人类脑组织各种脑结构的免疫反应。
结果
在8例阿尔茨海默病患者的杏仁核和额叶皮质中发现了针对小胶质细胞的核周抗体。在对照组中，有1名受试者显示出抗体与小胶质细胞结合。
结论
小胶质细胞核周抗体可能在阿尔茨海默病的组织破坏中起作用。这些数据进一步证明免疫机制在阿尔茨海默病的病理生理学中发挥作用。
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