在阿尔茨海默病患者而非唐氏综合征患者的血清中检测到脑自身抗体。
Detection of brain autoantibodies in the serum of patients with Alzheimer's disease but not Down's syndrome.
作者信息
Singh V K, Fudenberg H H
出版信息
Immunol Lett. 1986 Jun;12(5-6):277-80. doi: 10.1016/0165-2478(86)90030-1.
PMID:2942467
Abstract
The immunofluorescent staining of antibodies specifically binding to rat brain tissue sections was investigated in 95 human sera including 30 cases of Alzheimer's disease. A high incidence of specific antibrain antibody was found among Alzheimer's patients (57% positive) compared to other neurological disease controls (only 8% positive) or normal young and aged healthy controls (none positive).
摘要
在95份人血清中研究了与大鼠脑组织切片特异性结合的抗体的免疫荧光染色，其中包括30例阿尔茨海默病患者。与其他神经疾病对照者（仅8%呈阳性）或正常年轻和老年健康对照者（均无阳性）相比，在阿尔茨海默病患者中发现特异性抗脑抗体的发生率很高（57%呈阳性）。
Zotero 插件