Meier R, Hemmings B A
Friedrich Miescher Institute, Basel, Switzerland.
J Recept Signal Transduct Res. 1999 Jan-Jul;19(1-4):121-8. doi: 10.3109/10799899909036639.
Protein kinase B (PKB) is a member of the second-messenger regulated subfamily of protein kinases implicated in signalling downstream of growth factor and insulin receptor tyrosine kinases and phosphatidylinositol 3-kinase (PI 3-kinase). PKB is activated by phosphorylation in response to mitogens and survival factors. Membrane recruitment driven by lipid second-messengers derived from PI 3-kinase leads to PKB phosphorylation and activation by upstream kinases (PDK1 and an as yet identified protein kinase). Prolonged stimulation with growth factors results in nuclear translocation, providing evidence that PKB activation at the plasma membrane precedes its nuclear translocation and supporting a role for PKB in signalling from receptor tyrosine kinases to the nucleus.
蛋白激酶B（PKB）是蛋白激酶第二信使调节亚家族的成员，参与生长因子和胰岛素受体酪氨酸激酶以及磷脂酰肌醇3激酶（PI 3激酶）下游的信号传导。PKB通过响应有丝分裂原和存活因子的磷酸化而被激活。由PI 3激酶衍生的脂质第二信使驱动的膜募集导致PKB被上游激酶（PDK1和一种尚未确定的蛋白激酶）磷酸化并激活。生长因子的长期刺激导致核转位，这表明PKB在质膜上的激活先于其核转位，并支持PKB在从受体酪氨酸激酶到细胞核的信号传导中的作用。
