2-羟丙基-β-环糊精对甾体药物从栓剂基质中的体外释放作用。

The effect of 2-hydroxypropyl-beta-cyclodextrin on in vitro drug release of steroids from suppository bases.

作者信息

Usayapant A, Iyer B R

机构信息

Department of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL 60515, USA.

出版信息

Drug Dev Ind Pharm. 1999 Mar;25(3):387-90. doi: 10.1081/ddc-100102187.

DOI:10.1081/ddc-100102187

PMID:10071835

Abstract

The effects of 2-hydroxypropyl-beta-cyclodextrin (HPCD) on drug solubility and drug release from suppository bases were studied for dexamethasone (DX), dexamethasone acetate (DXA), hydrocortisone (HC), hydrocortisone acetate (HCA), and prednisolone acetate (PNA). It was found that HPCD significantly increased the aqueous solubility of all five steroids, and the increased drug solubility significantly influenced the drug release from the polyethylene glycol (PEG) base but not from the cocoa butter base.

摘要

研究了2-羟丙基-β-环糊精（HPCD）对醋酸地塞米松（DXA）、地塞米松（DX）、氢化可的松（HC）、醋酸氢化可的松（HCA）和醋酸泼尼松龙（PNA）在栓剂基质中的药物溶解度和药物释放的影响。发现HPCD显著提高了所有五种甾体药物的水溶性，且药物溶解度的增加显著影响了药物从聚乙二醇（PEG）基质中的释放，但对可可脂基质中的药物释放没有影响。