正常和心肌病仓鼠体内挥发性麻醉剂的最低肺泡麻醉浓度

Minimum alveolar anesthetic concentration of volatile anesthetics in normal and cardiomyopathic hamsters.

作者信息

Vivien B, Langeron O, Coriat P, Riou B

机构信息

Département d'Anesthésie-Réanimation, Centre Hospitalier Universitaire Pitié-Salpêtrière, Université Paris VI, France.

出版信息

Anesth Analg. 1999 Mar;88(3):489-93. doi: 10.1097/00000539-199903000-00004.

DOI:10.1097/00000539-199903000-00004

PMID:10071992

Abstract

UNLABELLED

Minimum alveolar anesthetic concentrations (MAC) values of volatile anesthetics in cardiovascular diseases remain unknown. We determined MAC values of volatile anesthetics in spontaneously breathing normal and cardiomyopathic hamsters exposed to increasing (0.1%-0.3% steps) concentrations of halothane, isoflurane, sevoflurane, or desflurane (n = 30 in each group) using the tail-clamp technique. MAC values and their 95% confidence interval were calculated using logistic regression. In normal hamsters, inspired MAC values were: halothane 1.15% (1.10%-1.20%), isoflurane 1.62% (1.54%-1.69%), sevoflurane 2.31% (2.22%-2.40%), and desflurane 7.48% (7.30%-7.67%). In cardiomyopathic hamsters, they were: halothane 0.89% (0.83%-0.95%), isoflurane 1.39% (1.30%-1.47%), sevoflurane 2.00% (1.85%-2.15%), and desflurane 6.97% (6.77%-7.17%). Thus, MAC values of halothane, isoflurane, sevoflurane, and desflurane were reduced by 23% (P < 0.05), 14% (P < 0.05), 13% (P < 0.05), and 7% (P < 0.05), respectively in cardiomyopathic hamsters.

IMPLICATIONS

Minimum alveolar anesthetic concentrations of volatile anesthetics were significantly lower in cardiomyopathic hamsters than in normal hamsters.

摘要

未标注

挥发性麻醉剂在心血管疾病中的最低肺泡有效浓度（MAC）值尚不清楚。我们采用尾夹技术，测定了暴露于递增浓度（以0.1%-0.3%的步长递增）的氟烷、异氟烷、七氟烷或地氟烷（每组n = 30）的自主呼吸正常仓鼠和心肌病仓鼠体内挥发性麻醉剂的MAC值。使用逻辑回归计算MAC值及其95%置信区间。在正常仓鼠中，吸入MAC值分别为：氟烷1.15%（1.10%-1.20%），异氟烷1.62%（1.54%-1.69%），七氟烷2.31%（2.22%-2.40%），地氟烷7.48%（7.30%-7.67%）。在心肌病仓鼠中，它们分别为：氟烷0.89%（0.83%-0.95%），异氟烷1.39%（1.30%-1.47%），七氟烷2.00%（1.85%-2.15%），地氟烷6.97%（6.77%-7.17%）。因此，在心肌病仓鼠中，氟烷、异氟烷、七氟烷和地氟烷的MAC值分别降低了23%（P < 0.05）、14%（P < 0.05）、13%（P < （此处原文有误，应是P < 0.05））和7%（P < 0.05）。