针对α-突触核蛋白的抗体在许多患有阿尔茨海默病的唐氏综合征患者大脑中检测到路易小体。
Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease.
作者信息
Lippa C F, Schmidt M L, Lee V M, Trojanowski J Q
机构信息
Department of Neurology, MCP-Hahnemann University, Philadelphia, PA 19129, USA.
出版信息
Ann Neurol. 1999 Mar;45(3):353-7. doi: 10.1002/1531-8249(199903)45:3<353::aid-ana11>3.0.co;2-4.
Immunohistochemical examination of 20 Down's syndrome brains, using antibodies to alpha-, beta-, and gamma-synuclein, demonstrated many alpha-synuclein-positive Lewy bodies and dystrophic neurites in 50% of amygdala samples from Down's syndrome brains with Alzheimer's disease. Similar lesions were less common in other regions of these brains, none of which contained beta-synuclein or gamma-synuclein abnormalities. Thus, alpha-synuclein-positive Lewy bodies and neuritic processes frequently occur with Alzheimer's disease in Down's syndrome brains.
使用针对α-、β-和γ-突触核蛋白的抗体，对20例唐氏综合征患者的大脑进行免疫组织化学检查，结果显示，在患有阿尔茨海默病的唐氏综合征患者大脑的50%杏仁核样本中，有许多α-突触核蛋白阳性的路易小体和营养不良性神经突。在这些大脑的其他区域，类似病变较少见，且均未发现β-突触核蛋白或γ-突触核蛋白异常。因此，α-突触核蛋白阳性的路易小体和神经突病变在唐氏综合征患者大脑中常与阿尔茨海默病同时出现。
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