含砷混合物在多器官致癌性生物测定中的拮抗相互作用。

Antagonistic interactions of an arsenic-containing mixture in a multiple organ carcinogenicity bioassay.

作者信息

Pott W A, Benjamin S A, Yang R S

机构信息

Department of Environmental Health, Center for Environmental Toxicology and Technology, Colorado State University, Fort Collins 80523-1680, USA.

出版信息

Cancer Lett. 1998 Nov 27;133(2):185-90. doi: 10.1016/s0304-3835(98)00229-8.

DOI:10.1016/s0304-3835(98)00229-8

PMID:10072168

Abstract

Inorganic arsenic (As), 1,2-dichloroethane (DCE), vinyl chloride (VC) and trichloroethylene (TCE) are frequently identified as groundwater contaminants near hazardous waste disposal sites. While the carcinogenicity of each of these chemicals has been extensively studied individually, little information exists regarding their carcinogenic potential in combination. Therefore, we investigated the carcinogenic promoting potential of chemical mixtures containing arsenic, DCE, VC and TCE following multiple initiator administration in a multiple organ carcinogenicity bioassay (N. Ito, T. Shirai, S. Fukushima, Medium-term bioassay for carcinogens using multiorgan models, in: N. Ito, H. Sugano (Eds.), Modification of Tumor Development in Rodents, Prog. Exp. Tumor Res., 33, 41-57, Basel, Karger, 1991). Our results reveal a dose-responsive antagonistic effect of this four-chemical mixture on the development of preneoplastic hepatic lesions (altered hepatocellular foci and glutathione S-transferase pi positive foci) as well as bronchioalveolar hyperplasia and adenoma formation.

摘要

无机砷（As）、1,2 - 二氯乙烷（DCE）、氯乙烯（VC）和三氯乙烯（TCE）常被认定为危险废物处置场地附近的地下水污染物。虽然已对这些化学物质各自的致癌性进行了广泛的单独研究，但关于它们联合作用下的致癌潜力却知之甚少。因此，我们在多器官致癌性生物测定中多次给予引发剂后，研究了含有砷、DCE、VC和TCE的化学混合物的致癌促进潜力（N. 伊藤、T. 白井、S. 福岛，使用多器官模型对致癌物进行中期生物测定，载于：N. 伊藤、H. 菅野（编），《啮齿动物肿瘤发展的改变》，《实验肿瘤研究进展》，第33卷，第41 - 57页，巴塞尔，卡尔格出版社，1991年）。我们的结果揭示了这种四化学物质混合物对癌前肝脏病变（肝细胞灶改变和谷胱甘肽S - 转移酶π阳性灶）以及支气管肺泡增生和腺瘤形成发展的剂量反应拮抗作用。