Klepikov N N, Khagundokova L B
Vopr Virusol. 1976 Jul-Aug(4):449-53.
H-2 antigens of mouse cells were shown to be incorporated into the Rauscher virus virion structure. Alloantibody to these antigens neutralized the infectious activity of the virus. Active immunization of mice with H-2 alloantigens reduces susceptibility of the animals to the virus. The experimental results suggest that alloantigens of host tissue compatibility incorporated into the virion membrane determine important immuno-biological properties of Rauscher virus.
已证明小鼠细胞的H-2抗原被整合到劳氏肉瘤病毒的病毒粒子结构中。针对这些抗原的同种抗体可中和病毒的感染活性。用H-2同种抗原对小鼠进行主动免疫可降低动物对该病毒的易感性。实验结果表明,整合到病毒粒子膜中的宿主组织相容性同种抗原决定了劳氏肉瘤病毒重要的免疫生物学特性。