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[一种新的牛痘感染实验模型]

[A new experimental model of vaccinia infection].

作者信息

Rytik P G, Boĭko V I, Votiakov V I, Pinchuk S I, Gudkov V G

出版信息

Vopr Virusol. 1976 Jul-Aug(4):465-8.

PMID:1007222
Abstract

The pathogenic, infectious, and immunogenic properties of vaccinia virus were studied in various species of small laboratory animals (mice of different ages, Syrian hamsters, guinea pigs, white and cotton rats, rabbits). Cotton rats were found to be most susceptible to the infection. Vaccinia virus in this species causes an acute, frequently lethal infection. The inoculated virus intensively accumulated in parenchymatous organs, and this was accompanied by a marked rise of hemagglutinating and virus-neutralizing antibody levels.

摘要

在各种小型实验动物(不同年龄的小鼠、叙利亚仓鼠、豚鼠、白大鼠和棉鼠、兔子)中研究了痘苗病毒的致病性、传染性和免疫原性。发现棉鼠对该感染最敏感。痘苗病毒在该物种中引起急性、常致命的感染。接种的病毒在实质器官中大量积聚,同时伴有血凝和病毒中和抗体水平的显著升高。

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