华法林在胸主动脉斑块合并心房颤动患者中的安全性和有效性。SPAF TEE研究人员。预防中风与心房颤动。经食管超声心动图检查。

Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation. SPAF TEE Investigators. Stroke Prevention and Atrial Fibrillation. Transesophageal echocardiography.

作者信息

Blackshear J L, Zabalgoitia M, Pennock G, Fenster P, Strauss R, Halperin J, Asinger R, Pearce L A

机构信息

Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA.

出版信息

Am J Cardiol. 1999 Feb 1;83(3):453-5, A9. doi: 10.1016/s0002-9149(98)00886-8.

DOI:10.1016/s0002-9149(98)00886-8

PMID:10072242

Abstract

Patients with atrial fibrillation and with documented aortic plaque who were assigned to adjusted-dose warfarin therapy (international normalized ratio 2.0 to 3.0) had an annual rate of cholesterol embolization of 0.7% (95% confidence interval [CI] 0.1% to 5.3%/patient-year). Warfarin-assigned patients with plaque had a lower rate of embolic events (5.9%/year; 95% CI 3.0 to 12) than those on combination low-dose warfarin (international normalized ratio <1.5) plus aspirin (17.3%/year; 95% CI 11 to 27; p = 0.01).

摘要

患有心房颤动且有主动脉斑块记录的患者，若接受调整剂量华法林治疗（国际标准化比值为2.0至3.0），胆固醇栓塞的年发生率为0.7%（95%置信区间[CI]为0.1%至5.3%/患者年）。分配接受华法林治疗且有斑块的患者，其栓塞事件发生率（5.9%/年；95%CI为3.0至12）低于接受低剂量华法林（国际标准化比值<1.5）加阿司匹林联合治疗的患者（17.3%/年；95%CI为11至27；p = 0.01）。